Michelangelo Buonarroti, according to psychiatrists could have suffered from Asperger's disorder, an interpretation that has been the subject of debate. A rare feature of Asperger syndrome is a prodigious eidetic memory, and, in this article, several facts are reviewed to prove its existence in Michelangelo, with special reference to the drawing of Laocoon's head in Michelangelo's secret room where he had to stay for months to escape from death. The findings and considerations described support the hypothesis about the suffering of Michelangelo from Asperger’s disorder.